Formulation and Comparative Evaluation of Aceclofenac Tablets by Two Granulation Methods

The objective of the present investigation was to design suitable Immediate release tablet formulation of Aceclofenac by using cross carmellose sodium as super-disintegrant in four different concentrations i.e., 0, 4, 6, 8% w/w of tablet weight by two granulation methods i.e., Wet and melt granulation methods. The objective of the research was to compare the two granulation methods i.e., wet and melt granulation methods. Melt granulation provides an advantageous method of granulation which results in a tablet dosage form showing immediate and fast release of drug. The main scope of this research work was to compare pre-compression, post-compression and in Vitro drug release properties of the tablets prepared by two granulation methods. Aceclofenac is an analgesic belonging to the class of NSAIDs. Four formulations (FW, F1, F2, and F3) of IR tablets were prepared by wet granulation method and four formulations of melt granulation (FM, F4, F5, and F6) were prepared. All the formulations were evaluated for their pre and post compression properties and also the in Vitro dissolution tests were carried out. It was found that the melt granulation formulations showed faster and immediate release compared to that of wet granulation method. Among all the formulations F6 formulation containing 8% CCS showed the faster drug release. Also the best formulations of both the granulation methods i.e., F3 and F6 were compared.